“While hydrogen’s antioxidant effects have been the primary focus of hundreds of studies since the 2007 Nature Medicine publication, I’m more intrigued by the studies suggesting that hydrogen regulates various signal transduction pathways. It is not surprising to me that hydrogen has therapeutic potential because we have always been exposed to it. For example, nearly 14 billion years ago, hydrogen was produced by the “Big Bang,” and 3.6 billion years ago the earth’s atmosphere was rich in hydrogen gas, which was essential in the genesis of life (e.g. hydrogenases, hydrogenosomes, mitochondria, etc.). Humans developed a symbiotic relationship with hydrogen-producing bacteria. Perhaps the reason that hydrogen has a beneficial biological effect is because we have been exposed to hydrogen gas since the dawn of time. I am extremely interested in knowing the primary targets of hydrogen gas”
Although the exact underlying molecular mechanisms and primary targets of hydrogen remain elusive, hydrogen may regulate these pathways via modifying lipid peroxidation cascades, protein phosphorylations, and gene expressions, resulting in anti-inflammatory, anti-allergy, and potential anti-aging benefits.
Due to the clinical significance of hydrogen, the goal of the science-based nonprofit Molecular Hydrogen Institute (MHI), is to help advance the research, education, and awareness of hydrogen as a therapeutic medical gas.”
Tyler W. LeBaron is the Founder and Executive Director of the science-based nonprofit Molecular Hydrogen Institute. His background is in biochemistry and exercise physiology. He was a 1-year Adjunct Instructor of Physiology, and interned at Nagoya University in the department of Neurogenetics to research the molecular mechanisms of hydrogen gas on cell signaling pathways. He is a director of the International Hydrogen Standards Association (IHSA) and the International Molecular Hydrogen Association (IMHA). He speaks at Medical conferences in the US for doctors CMEs/CEUs, and at academic biomedical hydrogen symposia and conferences around the world. He is also a member of the Academic Committee of Taishan Institute for Hydrogen Biomedical Research. He collaborates with researchers at home and abroad, and helps advance the education, research, and awareness of hydrogen as a therapeutic medical gas
Masters in Exercise and Sports Conditioning
Bachelor of Science in Biochemistry
Internship at Nagoya University Japan to research molecular mechanism of H2. Relevant course work include: Biochemistry, Physiology, Advanced Exercise Physiology, Nutritional Biochemistry, Molecular Cell Biology, Quantitative Chemical Analysis, Biology Analysis Techniques
Member of The American Chemical Society
Rotary Leadership Representative Councilor
Director of International Molecular Hydrogen Association (IMHA
Director of International Hydrogen Standards Association (IHSA)
Director of European Institute of Molecular Hydrogen (EIMH)
Academic Committee of Taishan Institute for Hydrogen Biomedical Research
Member of The American Chemical Society
Rotary Leadership Representative Councilor
2011-2013 Tutor Chemistry 481 (Biochemistry)
2012-2013 Tutor Biology 461 (Physiology)
2014-2015 Adjunct Instructor of Physiology at BYU-Idaho
2015-present Faculty of Academy of Comprehensive Integrative Medicine (ACIM)
2015-present Faculty of Age Management Medicine Group (AMMG)
Therapeutic effects of hydrogen gas
Free Radical Biology and Medicine
Therapeutic effects of electrolyzed reduced water
Therapeutic effects of exercise for disease prevention and treatment
Biological effects of inorganic nitrates
Biological and chemical properties of creatine
Vitamins, minerals and nutraceuticals
Supplements and ergogenic aids
Health, longevity and wellness
Physiology, biochemistry and organic chemistry
2019 LeBaron TW, Laher, I., Kura, B., & Slezak, J. Hydrogen gas: from clinical medicine to an emerging ergogenic molecule for sports athletes. Canadian journal of physiology and pharmacology, 2019; (in press)
2019 Korovljev, D., Stajer, V., Ostojic, J., LeBaron, T.W. & Ostojic, S.M., 2019. Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: a randomized controlled pilot trial. Clinics and research in hepatology and gastroenterology. 2019 April (in press)
2019 LeBaron TW, Larson A, Ohta S, Mikami T, Barlow J, Bulloch J, Debeliso M. Acute Supplementation with Molecular Hydrogen Benefits Submaximal Exercise Indices. Randomized, Double-Blinded, Placebo-Controlled Crossover Pilot Study. J. Lifestyle Medicine 2019; 9:36-43
2019 Kura B, Kalocayova B, LeBaron TW, Frimmel K, Buday J, Surovy J, Slezak J. Regulation of microRNAs by molecular hydrogen contributes to the prevention of radiation-induced damage in the rat myocardium. Molecular and Cellular Biochemistry. 2019 Mar 4:1-2.
2018 Kura B, Bagchi AK, Singal PK, Barancik M, LeBaron TW, Valachova K, Soltes L, Slezak J. Molecular hydrogen (H2): Potential in mitigating oxidative stress-induced cardiotoxicity. Canadian journal of physiology and pharmacology. 2018 Dec 13(ja).
2018 Jackson K, Dressler N, Ben-Shushan RS, Meerson A, LeBaron TW, Tamir S. Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model. World Journal of Gastroenterology. 2018 Dec 7;24(45):5095.
2018 Tyler W. LeBaron; Special Lecture: “Therapeutic and clinical effects of hydrogen gas” * Japanese-English translation, presented at medical-dental conference in Tokyo Japan (Dec. 15, 2018).
2018 Guo Q, Yin X, Qiao M, Jia Y, Chen D, Shao J, LeBaron TW, Gao Y, Jia B, Shi H. Hydrogen-rich water ameliorates autistic-like behavioral abnormalities in valproic acid-treated adolescent mice offspring. Frontiers in behavioral neuroscience. 2018;12:170.
2018 Tyler W. LeBaron; “Clinical effects of molecular hydrogen on neurodegenerative diseases” presented at Academy of Comprehensive Integrative Medicine. Orlando, Florida (Nov. 10th, 2015)
2018 Hirayama M, Ito M, Minato T, Yoritaka A, LeBaron TW, Ohno K. Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease. Medical gas research. 2018 Oct;8(4):144.
2018 Tyler W. LeBaron; “Inhalation of hydrogen gas mildly elevates oxidative stress in Parkinson’s disease. Hormetic or toxic?” presented at first International conference on Hydrogen Medicine and Biology Beijing China Oct. 13, 2018.
2018 Tyler W. LeBaron; “Beneficial effects of hydrogen gas- involvement of miRNAs, Co-Q10 and ATP production presented at the International Hydrogen Industry Development Forum, organized by International Molecular Hydrogen Association (IMHA) in Guangzhou, China (Sept. 15, 2018)
2018 Shang L, Xie F, Li J, Zhang Y, Liu M, Zhao P, Ma X, LeBaron TW. Therapeutic potential of molecular hydrogen in ovarian cancer. Translational Cancer Research. 2018 Aug 14;7(4):988-95.
2018 Tyler W. LeBaron; “Practical Applications and Clinical Uses for Molecular Hydrogen” presented at SOPMED Medical Conference in Colorado Springs, Colorado (June 22nd, 2018)
2018 Tyler W. LeBaron “Hydrogen: a therapeutic molecule for cardio and cerebrovascular diseases” presented at the 5th European Section meeting of the International Academy of Cardiovascular Sciences (IACS-ES) in Bratislava, Slovakia (May 24, 2018).
2018 M. Liang; Y. Du; W. Li; X. Yin; N. Yang; A. Qie; T. W. LeBaron; J. Zhang; H. Chen; H. Shi. “SuHeXiang essential oil inhalation produces antidepressant- and anxiolytic-like effects in adult mice” Biological and Pharmaceutical Bulletin. 2018 May 9:b18-00082
2018 Tyler W. LeBaron & Mark Rosenberg “Clinical Applications for Molecular Hydrogen” presented at the Academy of Anti-Aging Medicine (A4M) in Hollywood, Florida (April13, 2018).
2018 Tyler W. LeBaron; “Hydrogen: a biologically-regenerative molecule with clinical applications” presented at the Academy of Regenerative Practices in Boca Raton, Florida (March 3, 2018).
2017 Tyler W. LeBaron; “Is Hydrogen an Antioxidant? Definitions and Explanations” presented at the 4th Symposium of CPAM Chinese Hydrogen Biomedical Association (SCHBA) in Foshan, China (Dec. 6, 2017).
2017 Tyler W. LeBaron; “Hydrogen: an emerging medical gas with clinical significance” presented at 22nd International Conference of FFC-10th International Symposium of ASFFBC at Harvard Medical School, Boston MA, USA. (Sept. 23, 2017).
2017 Tyler W. LeBaron; “Molecular Hydrogen: from basic and clinical research to sports performance; an overview of the data from recent human studies” presented at the International Hydrogen Industry Development Forum, organized by International Molecular Hydrogen Association (IMHA) in Guangzhou, China (Sept. 14, 2017)
2017 Gao, Q., Song, H., Wang, X.T., Liang, Y., Xi, Y.J., Gao, Y., Guo, Q.J., LeBaron, T., Luo, Y.X., Li, S.C. and Yin, X. Molecular hydrogen increases resilience to stress in mice. Nature publication: Scientific Reports, 7 (2017)
2017 Tyler W. LeBaron; “Hydrogen: signal modulator for disease and inflammation” presented at SOPMED Medical Conference in Colorado Springs, Colorado (June 16th, 2017)
2017 Tyler W. LeBaron; “Hydrogen: A Therapeutic Medical Gas” presented at conference and medical group in Jakarta Indonesia (March 8, 2017)
2016 Tyler W. LeBaron; “Hydrogen Revolution in Industry and Medical Biology” presented at the Korea International Symposium on Hydrogen in Seoul Korea (November 25, 2016)
2016 Tyler W. LeBaron; “Hydrogen: A Small Molecule with Great Clinical Significance” presented at ILADS Annual Scientific Medical Conference on Lyme Disease in Philadelphia, PA (November 5, 2016)
2016 Tyler W. LeBaron; “Hydrogen: an Ageless Molecule of an Aging Society; a Scientific Basis for the Amelioration of Inflammation, Oxidation, and Cellular Degeneration” presented at the 3rd Symposium of Chinese Hydrogen Biomedical Association (SCHBA) in Taian city (September 25, 2016)
2016 Tyler W. LeBaron; “Hydrogen: an explosive molecule with explosive therapeutic effects” presented at the International Hydrogen Industry Development Forum, organized by International Molecular Hydrogen Association (IMHA) in Guangzhou, China (Sept. 9, 2016)
2016 Tyler W. LeBaron; “Hydrogen: A Therapeutic Molecule with Ergogenic Potential” presented at the 6th Hydrogen Medicine Conference in Shenyang, China (July 24, 2016)
2016 Tyler W. LeBaron; “Hidrógeno molecular: La revolución de Salud y el Bienestar, presented at Global Conference in Querétaro Mexico (July 12th, 2016)
2016 Tyler W. LeBaron; “Hydrogen Therapy: ‘Primum non nocere’ a revolution in health and wellness” presented at SOPMED Medical Conference in Salt Lake City, Utah (June 17th, 2016)
2016 Tyler W. LeBaron; “Hydrogen: A Unique and Superior Antioxidant Molecule for Athletes” presented at the International Molecular Hydrogen Symposium in Shanghai (March 20, 2016)
2015 Tyler LeBaron; “Molecular Hydrogen: therapeutic and medical applications” presented at Age Management Medical Group. Las Vegas, Nevada (Dec. 8th, 2015).
2015 Tyler LeBaron; “Molecular Hydrogen: therapeutic potential for neurodegenerative diseases” presented at Academy of Comprehensive Integrative Medicine. Orlando, Florida (Oct. 24th, 2015)
2015 Tyler LeBaron; “Molecular Hydrogen: therapeutic and medical applications” presented at FIME Medical Expo. Miami, Florida. (Aug. 7th, 2015).
2015 Tyler W. LeBaron; “Molecular Hydrogen: an evolutionary and molecular explanation for its ubiquitous biological effects on eukaryotes” presented at the 2nd Molecular Hydrogen Biomedical Symposium. CPMA Chinese Hydrogen Biomedical Association(June 28, 2015)
2015 Tyler W. LeBaron; “Molecular Hydrogen in America: research, products, media, and awareness” presented at 5thSymposium of Medical Molecular Hydrogen at Nagoya University (March 22, 2015) http://www.med.nagoya-u.ac.jp/neurogenetics/mmh2015/sub_program.html
2014 Meyers, Jonathan K., Tyler W. LeBaron, and David C. Collins. “The Journal of Kitchen Chemistry: A Tool for Instructing the Preparation of a Chemistry Journal Article.” Journal of Chemical Education. http://pubs.acs.org/doi/abs/10.1021/ed400671y
2013 Tyler W. LeBaron; “Changes in Oxidation-Reduction Potential of Aqueous Solutions as a Function of pH and Hydrogen Gas Concentration” The Journal of Kitchen Chemistry 2013. 1. P.12
2013 Tyler W. LeBaron; “Estimation of Hydrogen gas Concentration in Aqueous Solutions via Oxidation-Reduction Potential Measurements as a Function of pH” presented at BYU-I Research and Creative Works Conference, April 4, 2013. http://beta.byui.edu/Documents/instructional_development/rcw/2013%20Winter/RCW%20Winter%202013%20%282%29.pdf
2012 Tyler W. LeBaron; Determination of nitrate reduction in the presence of ascorbic acid at facilitative pH (Personal project—preliminary results and specific review presented in 2012).
2012 Tyler W. LeBaron; “Testosterone Booster Recommendation Report” (A critical review of purported supplements) http://scholar.google.com/scholar?q=%22Testosterone+Booster+Recommendation+Report%22&btnG=&hl=en&as_sdt=0%2C13
2011 Tyler W. LeBaron; “Creatine recommendation report” (Review of current work and elucidation of creatine stability with respect to various supplements http://scholar.google.com/scholar?q=%22creatine+recommendation+report%22+&btnG=&hl=en&as_sdt=0%2C13
2010 Tyler W. LeBaron; “Functional Water for the Prevention and Treatment of Disease (A comprehensive literature review)”, presented at BYU-I Research and Creative Works Conference, December 9, 2010. http://emp.byui.edu/PyperB/2010FallUGRC.htm
2010 Tyler W. LeBaron “Alkaline Reduced (electrolyzed) Water enhances time to exhaustion during lactate threshold running”, presented at BYU-I Research and Creative Works Conference, Mar 25, 2010
Note: This article comes from Molecular Hydrogen Institute (MHI)